Benoît Rigo was born in 1946 in Paris, France. After an Engineer diploma in textile chemistry from the Institut Technique Roubaisien, he obtained in 1975 a PhD-Engineer in Organic Chemistry from the University of Lille under the supervision of Professor P. Pigache, then became associate professor of organic chemistry in the Hautes Etudes d’Ingénieurs de Lille (HEI). In 1981 he worked a brief time at PennState under the supervision of Professor R. A. Olofsons on the decarboxyethylation of enaminoesters. His work on pyroglutamic acid chemistry allowed him to became Docteur-ès-Science in 1984. While working on HMG-CoA reductase inhibitors, he also obtained in 1992 a ‘Mastère’ degree in Drug Design from the Ecole Nationale Supérieure de Chimie de Lille (ENSCL) and the Albert Lespagnol Institute of Pharmaceutical Chemistry (ICPAL). Since 1984 he is a full Professor at HEI and directs his Laboratory of Pharmaceutical Chemistry, now part of the EA 4481 of Lille 2 University. In the field of bioactive compounds, he worked inter alia on fungicide products, on potassium channel openers, inhibitors of topoisomerases, of protein mTor, and is currently interested on the inhibition of protein farnesyltransferase, of tubulin polymerization and of P2X7 channel. However, his other interest is the chemistry of pyroglutamic acid, considered as a scaffold for heterocyclic syntheses, and the many ways for theses derivatives to produce N-acyliminium salts.