RICT 2014
Conferences > Archives > RICT 2014
Wednesday July 2, 2014
13:45Opening Ceremony
Prof. Xavier PANNECOUCKE
(INSA ROUEN, Saint Etienne du Rouvray, France)
Prof. Hubert VAUDRY
(UNIVERSITY OF ROUEN, Mont-Saint-Aignan, France)

(THERMO FISHER SCIENTIFIC)
Mr Nicolas MAYER-ROSSIGNOL
(PRÉSIDENT DU CONSEIL RÉGIONAL DE HAUTE-NORMANDIE, Rouen, France)
Mr Frédéric SANCHEZ
(PRÉSIDENT DE LA CREA, Rouen, France)
Dr Pascal GEORGE
(SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France)
Session 1: Ehrlich Prize
Sponsored by Janssen-Cilag
Session Chair:
Dr Jean-François BONFANTI
(JANSSEN R&D, Val de Reuil, France)
14:00Ehrlich Prize Winner
Natural Antitumor Macrolides Acting on Tubulin: Synthesis and Functional Exploration
Prof. Karl-Heinz ALTMANN
(SCS DMCCB & SWISS FEDERAL INSTITUTE OF TECHNOLOGY, Zurich, Switzerland)
Session 2: Epigenetics
Session Chair:
Dr Luc VAN HIJFTE
(SCT & NOVALIX, Nijmegen, The Netherlands)
15:00Discovery and Optimisation of a Novel Series of EZH2 Inhibitors, Challenges and Clinical Perspectives
Dr Jean-Christophe HARMANGE
(CONSTELLATION PHARMACEUTICALS, Cambridge, United States)
15:45Coffee Break and Exhibition
Session 3: Stabilized Peptides
Sponsored by Ipsen
Session Chair:
Dr Olivier LAVERGNE
(., Palaiseau, France)
16:452-Clips Peptides: A Novel Class of Biopharmaceuticals
Prof. Peter TIMMERMAN
(PEPSCAN THERAPEUTICS, Lelystad, The Netherlands)
17:30Design and Applications of Protein Epitope Mimetics
Prof. John ROBINSON
(UNIVERSITY OF ZÜRICH, Zürich, Switzerland)
18:30Welcome Reception
20:30Public Lecture: La recherche des médicaments d’hier à aujourd’hui
Open to the general public of Rouen and all symposium participants (venue: Hôtel de Région, room Hémicycle)
Prof. Jean COSTENTIN
(UNIVERSITY OF ROUEN, Rouen, France)
Thursday July 3, 2014
Session 4: Molecular Space
Sponsored by LabEx SynOrg
Session Chair:
Prof. Xavier PANNECOUCKE
(INSA ROUEN, Saint Etienne du Rouvray, France)
08:30Excursions in Uncharted Structural Space
Prof. Erick M. CARREIRA
(ETH ZÜRICH, Zürich, Switzerland)
Session 5: Short Communications
Sponsored by SCT
Session Chair:
Prof. Patrick DALLEMAGNE
(UNIVERSITY OF CAEN, Caen, France)
09:15Silicon-containing Tetrahydrocyclopenta[c]acridine Derivatives as CDKs Inhibitors: Design, Organometallic Synthesis, Metabolic Stability and Optimisation
Prof. Philippe BELMONT
(UNIVERSITY PARIS DESCARTES, Paris, France)
09:45Combining Organic Synthesis, Software Development and Biochemistry for the Design and Discovery of Prolyl oligopeptidase Inhibitors
Prof. Nicolas MOITESSIER
(MCGILL UNIVERSITY, Montreal, Canada)
Session Chair:
Prof. Nicolas WILLAND
(UNIVERSITY OF LILLE, Lille, France)
09:15Identification of Cell-penetrating Compounds and their Use for Intracellular Delivery of Cathepsin D Inhibitors
Prof. Muriel AMBLARD
(CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France)
09:45Innovative Fluorescent-Based Approaches to GPCR Screening and Functional Architecture Studies
Prof. Dominique BONNET
(UNIVERSITY OF STRASBOURG, Illkirch, France)
10:15Coffee Break, Exhibition and Poster Session (odd numbers)
Session 7: Cardiac/Geno Safety Session 6: Protein-protein Interactions
Sponsored by ACS
Session Chair:
Prof. Gérard SIEST
(UNIVERSITY OF LORRAINE & PRESIDENT OF THE EUROPEAN SOCIETY OF PHARMACOGENOMICS AND THERANOSTICS, Nancy, France)
11:00Genotoxicity Screening can guide Lead Optimisation and Reduce Late Stage Attrition
Prof. Richard WALMSLEY
(UNIVERSITY OF MANCHESTER, Manchester, United Kingdom)
11:45Recent Advances in Predicting Cardiac Risk during Drug Development
Dr Arthur BROWN
(CHANTEST, Cleveland, United States)
Session Chair:
Dr Gilles GUICHARD
(CBMN & IECB, UNIVERSITY OF BORDEAUX, CNRS, BORDEAUX INP, Pessac, France)
11:00Use of Peptides to Modulate Protein-Protein Interactions
Prof. Ernest GIRALT
(INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB), Barcelona, Spain)
11:45Strategies to Target Protein-Protein Interactions: from Discovery to Clinical Development
Prof. Shaomeng WANG
(UNIVERSITY OF MICHIGAN, Michigan, United States)
12:30Lunch
13:15Exhibition and Poster Session (Odd numbers)
14:00Career Session
Session 8: OncologySession 9: Biophysic tools and SPR
Sponsored by NovAliX
Session Chair:
Dr Kam ZHANG
(RIKEN, Yokohama, Japan)
14:30Targeting BAX for Cancer Therapy: from Computer Screen to Mouse
Dr Luciana MARINELLI
(UNIVERSITY OF NAPOLI, Napoli, Italy)
15:15Discovery of TAK-632: Pan-RAF Inhibitor with Potent Antitumor Activity against BRAF and NRAS Mutant Melanomas
Dr Masanori OKANIWA
(TAKEDA PHARMACEUTICAL COMPANY, Kanagawa, Japan)
Session Chair:
Dr Denis ZEYER
(NOVALIX, Illkirch, France)
14:30Exploiting the Information Rich Output of SPR Biosensor Technology in Drug Discovery – From Target Evaluation to Fragment and Lead
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
15:15High-Throughput Chemical Microarray SPR: The Biophysical Tool for Fragment Based Screening in Drug Discovery
Dr Thomas NEUMANN
(GRAFFINITY PHARMACEUTICALS, Illkirch, France)
16:00Coffee Break and Exhibition
Session 10: Epigenetics
Sponsored by Inventiva
Session 11: Biophysics and Kinetics
Session Chair:
Dr Alexis DENIS
(GSK, Courtaboeuf, France)
16:30Cell Identity Loss in Cancer: a Source of New Biomarkers and Therapeutic Targets
Dr Saadi KHOCHBIN
(JOSEPH FOURIER UNIVERSITY, Grenoble, France)
17:15Chemical Probes for Epigenetics
Dr Dafydd OWEN
(PFIZER, Cambridge, United States)
Session Chair:
Dr Frank LEEMHUIS
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands)
16:30Translational Biophysics: Using Biophysical Data in Medicinal Chemistry
Dr Matthias FRECH
(MERCK, Darmstadt, Germany)
17:15Molecular Basis of Ligand Dissociation from GPCRs – a Molecular Dynamics and Mutagenesis Study on the Adenosine A2A Receptor
Dr Laura HEITMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands)
Session 12: Physicochemical Properties
Session Chair:
Dr Gerardo TURCATTI
(ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland)
18:00Polar Units and Dipolar Interactions Modulating, Conformation, Lipophilicity, and other Physicochemical Properties
Prof. Klaus MÜLLER
(F. HOFFMANN-LA ROCHE, Switzerland)
20:00Symposium Banquet
Friday July 4, 2014
Session 13: Kinases
Sponsored by Servier
Session Chair:
Dr Arnaud LE TIRAN
(INSTITUT DE RECHERCHES SERVIER, Croissy sur Seine, France)
08:30The Lab Oddity Prevails - Discovery of pan-CDK Inhibitor BAY 1000394 (Roniciclib) for the Treatment of Cancer
Dr Ulrich LÜCKING
(BAYER HEALTHCARE, Berlin, Germany)
09:15The Design and Optimisation of Selective Protein Kinase C Theta Inhibitors for the Treatment of Autoimmune Diseases
Dr Juan-Miguel JIMENEZ
(VERTEX PHARMACEUTICALS, Abingdon, United Kingdom)
10:00Coffee Break, Exhibition and Poster Session (Even numbers)
Session 14: Non Standard Tools
Session Chair:
Dr Kenichiro KATAOKA
(TEIJIN PHARMA LIMITED, Tokyo, Japan)
10:45Specific Antidotes for Dabigatran: Structure-Guided Affinity Optimisation and Functional Characterisation
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
11:30Pseudo-Natural Product Synthesis and Drug Applications
Prof. Hiroaki SUGA
(UNIVERSITY OF TOKYO, Tokyo, Japan)
12:30Lunch
13:00Exhibition and Poster Session (Even numbers)
Session 15: CNS - Psychiatry
Session Chair:
Dr Dominique LESUISSE
(SCT & SANOFI, Chilly-Mazarin, France)
14:00PDE10A Inhibitors as Potential Treatments for Schizophrenia
Dr Jose Manuel BARTOLOME
(JANSSEN RESEARCH & DEVELOPMENT, Toledo, Spain)
14:45Novel Imidazoles as Selective TAAR1 Partial Agonists for the Treatment of Psychiatric Disorders
Dr Giuseppe CECERE
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)
Session 16: Pierre Fabre Award for Therapeutic Innovation
Sponsored by Pierre Fabre
Session Chair:
Dr PHILIPPE MAILLOS
(INSTITUT DE RECHERCHE PIERRE FABRE, CASTRES, France)
15:30Pierre Fabre Lecture
Prof. Sebastien PAPOT
(SCT & UNIVERSITY OF POITIERS, Poitiers, France)
Session 17: Closing
Session Chair:
Prof. Janos SAPI
(SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France)
16:15Prizes and Closing Remarks
Session Chair:
Dr Christine CONTINO-PEPIN
(UNIVERSITY OF AVIGNON, Avignon, France)
16:25RICT 2015
16:30End of the Symposium

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