2nd NovAliX Conference - Biophysics in Drug Discovery 2015

Scientific Programme

Tuesday June 9, 2015
11:00Registration
13:30Welcome Address
SESSION 1: Method Development & Emerging Technologies
Session Chair
Dr Johannes OTTL
(NOVARTIS INSTITUTE OF BIOMEDICAL RESEARCH, Basel, Switzerland)
13:45Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Dr Pär NORDLUND
(KAROLINSKA INSTITUTE & NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, Singapore)
14:30No Crystal, No Problem: Hydrogen Deuterium Exchange Mass Spectrometry in Drug Discovery
Dr Nino CAMPOBASSO
(GLAXOSMITHKLINE, Collegeville, United States)
15:15Strategies to Target Protein-Protein Interactions
Dr Marta WESTWOOD
(UCB, Slough, United Kingdom)
15:40Coffe break & exhibition
16:10Characterization of IL17A Inhibitors by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)
Mr Alfonso ESPADA
(ELI LILLY, MADRID, Spain)
16:35Second-Harmonic Generation (SHG) Measures and Resolves Protein Conformations: High-Throughput Structural Drug Discovery
Dr Joshua SALAFSKY
(BIODESY, South San Francisco, United States)
KEYNOTE LECTURE
Chair
Dr Ursula EGNER
(BAYER, Berlin, Germany)
17:20Molecular Recognition in Protein-Ligand Complexes
Prof. Gerhard KLEBE
(PHILIPPS-UNIVERSITY MARBURG, Marburg, Germany)
18:20Welcome Reception
19:35End of Day 1
Wednesday June 10, 2015
08:30Registration
SESSION 2: Biophysics for Integral Membrane Proteins
Session Chair
Dr Vincent MIKOL
(SANOFI, Vitry-sur-Seine, France)
09:00Improving the Biophysical Properties of GPCRs for Drug Screening and Structural Biology
Prof. Andreas PLÜCKTHUN
(UNIVERSITY OF ZÜRICH, Zurich, Switzerland)
09:45Fluorine NMR Screening: Principles and Application to a Membrane Protein
Dr Claudio DALVIT
(UNIVERSITY OF NEUCHÂTEL, Neuchâtel, Switzerland)
10:30Coffee break & exhibition
11:00Drug Discovery at the Single Molecule Level
Dr Anders GUNNARSSON
(ASTRAZENECA, Mölndal, Sweden)
11:25First Crystal Structure of Transmembrane Domain of G-Protein-Coupled Receptor MGLU5 Provides Insight Into Efficient New Drugs Design
Dr Krzysztof OKRASA
(HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom)
SESSION 4 (anticipated): The Use of Kinetics in Drug Discovery
Session Chair
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom)
11:50Towards a Better Understanding of the Structural Mechanisms of Kinase Inhibitor Binding Kinetics
Prof. Stefan KNAPP
(OXFORD UNIVERSITY, Oxford, United Kingdom)
12:35Lunch, exhibition & networking
SESSION 3: Impact of Biophysics on Drug Discovery Projects
Session Chair
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
14:15Some Examples of Biophysics Helping Drug Discovery
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom)
15:00Making Every Interaction Count: Impact of Biophysical Methods Across the AstraZeneca Small-Molecule Portfolio
Dr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden)
15:45Coffee break & exhibition
16:15Biophysical Approaches for Hit Finding and Evaluation at Bayer
Dr Ursula EGNER
(BAYER, Berlin, Germany)
17:00Biophysics and Structural Biology Enabling the Discovery of Therapeutic Solutions: from Small Molecule Inhibitors to Vaccine Design
Dr Vincent MIKOL
(SANOFI, Vitry-sur-Seine, France)
17:45End of Day 2
Thursday June 11, 2015
SESSION 4: The Use of Kinetics in Drug Discovery
Session Chair
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom)
09:15CCR2 Antagonists: From Structure-Kinetics Relatiosnhips to in vivo Efficacy
Dr Laura HEITMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands)
10:00A Universal Homogeneous Assay for High-Throughput Determination of Binding Kinetics
Dr Amaury Ernesto FERNANDEZ MONTALVAN
(BAYER, Berlin, Germany)
10:25Coffee break & exhibition
10:55CDK8 Inhibitors with Long Residence Time Emerging from a Retro-Design Approach: New Opportunities for Cancer Treatment
Dr Anita WEGERT
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands)
11:20Analysis of Binding Kinetics and Thermodynamics of DPP-4 Inhibitors and their Relationship to Structure
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
12:05Lunch, exhibition & networking
13:45Poster Session
16:00Coffe break & exhibition
16:30Round Table Discussion
The Round Table will sum up the topics discussed in the first four Sessions of this Conference
Chair
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom)
17:15Poster Prizes
17:25End of Day 3
20:00Conference Dinner at the Restaurant Maison Kammerzell
(optional, subject to prior booking)
Friday June 12, 2015
SESSION 5: Special Focus on Epigenetics
Session Chair
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
09:15Interrogating the Bromodomain Family Through Chemical Biology
Dr Richard CUMMINGS
(CONSTELLATION PHARMACEUTICALS, Cambridge, United States)
10:00When to get Biophysical with Readers, Writers and Erasers
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
10:45Coffee break & exhibition
11:15Protein Methyltransferase Inhibitors as Personalised Cancer Therapeutics
Dr Robert A. COPELAND
(EPIZYME, Cambridge, United States)
12:00Closing Remarks
12:15End of Day 4
14:15Guided tour of the Cathedral of Strasbourg
(subject to prior registration)

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