Tuesday June 9, 2015 |
11:00 | Registration |
|
13:30 | Welcome Address |
|
| SESSION 1: Method Development & Emerging Technologies |
|
| Session Chair |
Dr Johannes OTTL (NOVARTIS INSTITUTE OF BIOMEDICAL RESEARCH, Basel, Switzerland) |
13:45 | Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay |
Dr Pär NORDLUND (KAROLINSKA INSTITUTE & NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, Singapore) |
14:30 | No Crystal, No Problem: Hydrogen Deuterium Exchange Mass Spectrometry in Drug Discovery |
Dr Nino CAMPOBASSO (GLAXOSMITHKLINE, Collegeville, United States) |
15:15 | Strategies to Target Protein-Protein Interactions |
Dr Marta WESTWOOD (UCB, Slough, United Kingdom) |
15:40 | Coffe break & exhibition |
|
16:10 | Characterization of IL17A Inhibitors by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) |
Mr Alfonso ESPADA (ELI LILLY, ALCOBENDAS, Spain) |
16:35 | Second-Harmonic Generation (SHG) Measures and Resolves Protein Conformations: High-Throughput Structural Drug Discovery |
Dr Joshua SALAFSKY (BIODESY, South San Francisco, United States) |
| KEYNOTE LECTURE |
|
| Chair |
Dr Ursula EGNER (BAYER, Berlin, Germany) |
17:20 | Molecular Recognition in Protein-Ligand Complexes |
Prof. Gerhard KLEBE (PHILIPPS-UNIVERSITY MARBURG, Marburg, Germany) |
18:20 | Welcome Reception |
|
19:35 | End of Day 1 |
|
Wednesday June 10, 2015 |
08:30 | Registration |
|
| SESSION 2: Biophysics for Integral Membrane Proteins |
|
| Session Chair |
Dr Vincent MIKOL (SANOFI, Vitry-sur-Seine, France) |
09:00 | Improving the Biophysical Properties of GPCRs for Drug Screening and Structural Biology |
Prof. Andreas PLÜCKTHUN (UNIVERSITY OF ZÜRICH, Zurich, Switzerland) |
09:45 | Fluorine NMR Screening: Principles and Application to a Membrane Protein |
Dr Claudio DALVIT (UNIVERSITY OF NEUCHÂTEL, Neuchâtel, Switzerland) |
10:30 | Coffee break & exhibition |
|
11:00 | Drug Discovery at the Single Molecule Level |
Dr Anders GUNNARSSON (ASTRAZENECA, Mölndal, Sweden) |
11:25 | First Crystal Structure of Transmembrane Domain of G-Protein-Coupled Receptor MGLU5 Provides Insight Into Efficient New Drugs Design |
Dr Krzysztof OKRASA (HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom) |
| SESSION 4 (anticipated): The Use of Kinetics in Drug Discovery |
|
| Session Chair |
Dr Geoff HOLDGATE (ASTRAZENECA, Macclesfield, United Kingdom) |
11:50 | Towards a Better Understanding of the Structural Mechanisms of Kinase Inhibitor Binding Kinetics |
Prof. Stefan KNAPP (OXFORD UNIVERSITY, Oxford, United Kingdom) |
12:35 | Lunch, exhibition & networking |
|
| SESSION 3: Impact of Biophysics on Drug Discovery Projects |
|
| Session Chair |
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
14:15 | Some Examples of Biophysics Helping Drug Discovery |
Prof. Rod HUBBARD (UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom) |
15:00 | Making Every Interaction Count: Impact of Biophysical Methods Across the AstraZeneca Small-Molecule Portfolio |
Dr Stefan GESCHWINDNER (ASTRAZENECA, Mölndal, Sweden) |
15:45 | Coffee break & exhibition |
|
16:15 | Biophysical Approaches for Hit Finding and Evaluation at Bayer |
Dr Ursula EGNER (BAYER, Berlin, Germany) |
17:00 | Biophysics and Structural Biology Enabling the Discovery of Therapeutic Solutions: from Small Molecule Inhibitors to Vaccine Design |
Dr Vincent MIKOL (SANOFI, Vitry-sur-Seine, France) |
17:45 | End of Day 2 |
|
Thursday June 11, 2015 |
| SESSION 4: The Use of Kinetics in Drug Discovery |
|
| Session Chair |
Dr Geoff HOLDGATE (ASTRAZENECA, Macclesfield, United Kingdom) |
09:15 | CCR2 Antagonists: From Structure-Kinetics Relatiosnhips to in vivo Efficacy |
Prof. Laura HEITMAN (UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
10:00 | A Universal Homogeneous Assay for High-Throughput Determination of Binding Kinetics |
Dr Amaury FERNANDEZ MONTALVAN (BAYER, Biberach an der Riss, Germany) |
10:25 | Coffee break & exhibition |
|
10:55 | CDK8 Inhibitors with Long Residence Time Emerging from a Retro-Design Approach: New Opportunities for Cancer Treatment |
Dr Anita WEGERT (MERCACHEM-SYNCOM, Nijmegen, The Netherlands) |
11:20 | Analysis of Binding Kinetics and Thermodynamics of DPP-4 Inhibitors and their Relationship to Structure |
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
12:05 | Lunch, exhibition & networking |
|
13:45 | Poster Session |
|
16:00 | Coffe break & exhibition |
|
16:30 | Round Table Discussion
The Round Table will sum up the topics discussed in the first four Sessions of this Conference |
|
| Chair |
Prof. Rod HUBBARD (UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom) |
17:15 | Poster Prizes |
|
17:25 | End of Day 3 |
|
20:00 | Conference Dinner at the Restaurant Maison Kammerzell (optional, subject to prior booking) |
|
Friday June 12, 2015 |
| SESSION 5: Special Focus on Epigenetics |
|
| Session Chair |
Prof. Helena DANIELSON (UPPSALA UNIVERSITY, Uppsala, Sweden) |
09:15 | Interrogating the Bromodomain Family Through Chemical Biology |
Dr Richard CUMMINGS (CONSTELLATION PHARMACEUTICALS, Cambridge, United States) |
10:00 | When to get Biophysical with Readers, Writers and Erasers |
Dr Chun-wa CHUNG (GLAXOSMITHKLINE, Stevenage, United Kingdom) |
10:45 | Coffee break & exhibition |
|
11:15 | Protein Methyltransferase Inhibitors as Personalised Cancer Therapeutics |
Dr Robert A. COPELAND (EPIZYME, Cambridge, United States) |
12:00 | Closing Remarks |
|
12:15 | End of Day 4 |
|
14:15 | Guided tour of the Cathedral of Strasbourg (subject to prior registration) |
|