| Wednesday July 5, 2017 |
| 08:00 | Registration & Welcome Coffee |
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| 09:30 | RICT 2017 Opening |
Michel BALTAS (CNRS, UNIVERSITY OF TOULOUSE, Toulouse, France)
Armand LATTES (UNIVERSITE PAUL SABATIER, Toulouse, France)
Alexis VALENTIN (UNIVERSITÉ PAUL SABATIER, Toulouse, France)
Luc VAN HIJFTE (SCT & NOVITHERA, Nijmegen, The Netherlands) |
| Session 1: Paul Ehrlich Award Lecture
Sponsored by Janssen Research & Development |
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| Session Chairs |
Jean-François BONFANTI (JANSSEN R&D, Val de Reuil, France)
Luc VAN HIJFTE (SCT & NOVITHERA, Nijmegen, The Netherlands) |
| 10:00 | PL01 - Sugars & Proteins: Glycomimetics to Target Infectious Disease |
Benjamin DAVIS
(OXFORD UNIVERSITY, Oxford, United Kingdom) |
| 11:00 | Coffee break & Exhibition |
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| Session 2: Peptides & Sugars in Drug Discovery |
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| Session Chair |
Olivier LAVERGNE
(, Palaiseau, France) |
| 11:30 | PL02 - Peptide Drugs to Target GPCR- State of the Art and Innovative Application |
Annette BECK-SICKINGER
(LEIPZIG UNIVERSITY, Leipzig, Germany) |
| 12:15 | Lunch break & Exhibition |
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| 13:00 | Poster Session 1 (odd numbers) & Exhibition |
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| Session 3: Recent Advances in Immuno-oncology
Sponsored by Evotec |
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| Session Chair |
Gilbert LASSALLE
(EVOTEC, Toulouse, France) |
| 14:30 | PL03 - Small Molecule Approaches in Immune Modulation in Cancer. |
Ronan O'HAGAN
(MERCK, SHARP & DOHME, Boston, United States) |
| 15:15 | PL04 - Immunotherapy of Cancers: The Lessons of Oncodermatology; Melanoma as a Model |
Nicolas MEYER
(ONCOPOLE TOULOUSE, Toulouse, France) |
| 16:00 | Coffee break & Exhibition |
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| 16:30 | PL05 - Novel Small Molecule MerTK Inhibitors and their Biological Uses |
Xiaodong WANG
(UNIVERSITY OF NORTH CAROLINA, Chapel Hill, United States) |
| 17:15 | PL06 - Discovery of PF-06840003, a Novel IDO Inhibitor for Cancer Immunotherapy |
Stefano CROSIGNANI
(ITEOS THERAPEUTICS SA, Gosselies, Belgium) |
| 18:00 | Welcome & Networking Reception |
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| 19:30 | End of Day 1 |
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| Thursday July 6, 2017 |
| Session 4: Inspired by Nature |
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| Session Chair |
Michel BALTAS
(CNRS, UNIVERSITY OF TOULOUSE, Toulouse, France) |
| 08:30 | PL07 - De Novo Drug Design — Inspiration from Nature |
Gisbert SCHNEIDER
(ETH ZÜRICH, Zürich, Switzerland) |
| Session 4: Inspired by Nature | Session 5: Advances in Kinase Inhibitors Discovery |
| Session Chair |
Michel BALTAS
(CNRS, UNIVERSITY OF TOULOUSE, Toulouse, France) |
| 09:15 | KL01 - New Modalities inspired by nature: from Genetic Encoding of Cyclic Peptides to Hybrid Macrocycles |
Eric VALEUR
(ASTRAZENECA, IMED BIOTECH UNIT, Cambridge, United States) |
| 09:45 | KL03 - Post-functionalization of RNAs for Specific Conjugations with Peptides and Proteins |
Mélanie ETHEVE-QUELQUEJEU
(UNIVERSITY PARIS DESCARTES, Paris, France) |
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| Session Chair |
Jean-Yves ORTHOLAND
(EDELRIS, Lyon, France) |
| 09:15 | KL02 - Mnk1/2 Kinase Inhibitors for the Treatment of Leukemia |
Kassoum NACRO
(EXPERIMENTAL THERAPEUTICS CENTER, Singapore, Singapore) |
| 09:45 | KL04 - Discovery of CDK8/CDK19 Kinase Modulators and Evaluation of their Therapeutic Potential |
Aurelie MALLINGER
(INSTITUTE OF CANCER RESEARCH, London, United Kingdom) |
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| 10:15 | Coffee break & Exhibition |
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| Session 6: Accessing Novel Chemical Space | Session 7: Structure Based Design |
| Session Chair |
Janos SAPI
(SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France) |
| 10:45 | PL08 - Expanding Screening Decks by Innovative MCR Scaffolds |
Alexander DÖMLING
(UNIVERSITY OF GRONINGEN, Groningen, The Netherlands) |
| 11:30 | PL10 - Chemoselective and Biocompatible Reactions, New Tools for Heterocyclic Chemistry and Chemical Biology |
Frédéric TARAN
(CEA/SACLAY, Gif-sur-Yvette, France) |
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| Session Chair |
Jean-Paul RENAUD
(RIBOSTRUCT, Ostwald, France) |
| 10:45 | PL09 - First-in-class Extracellular Modulators of Receptor Tyrosine Kinases: from Theory to Practice |
Didier ROGNAN
(CNRS/UNIVERSITY OF STRASBOURG, Illkirch, France) |
| 11:30 | PL11 - Structure-based Drug Design (SBDD) in Medicinal Chemistry-enabled Drug Discovery |
Hong SHEN
(ROCHE INNOVATION CENTER, Shanghai, China) |
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| 12:15 | Lunch break & Exhibition |
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| 13:00 | Poster Session 2 (even numbers) & Exhibition |
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| 13:45 | Career Session |
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| Session 8: New Tools for Therapeutic Innovation | Session 9: Advances in Proteases Inhibitor Discovery |
| Session Chair |
YVES GENISSON
(UNIVERSITE PAUL SABATIER - LSPCMIB, Toulouse, France) |
| 14:30 | KL05 - Copper and Zinc as Therapeutic Players in Alzheimer's Disease: With a little Help from Coordination Chemistry. |
Christelle HUREAU
(LCC CNRS, Toulouse, France) |
| 15:00 | KL07 - Nanometric Micelles for in vivo Imaging and Drug Delivery |
Eric DORIS
(CEA, Gif-sur-Yvette, France) |
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| Session Chair |
Patrick JIMONET
(SANOFI, Vitry sur Seine, France) |
| 14:30 | KL06 - Discovery of Novel TACE Inhibitors for Topical Treatment of Psoriasis |
Gilles OUVRY
(GALDERMA R&D, Sophia Antipolis, France) |
| 15:00 | KL08 - Mining from NP-Like Fragments in 3D: Discovery of a Potent Caspase-1 Inhibitor |
Vincent RODESCHINI
(EDELRIS, LYON, France) |
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| Session 10: Rare Diseases | Session 11: Neglected Diseases |
| Session Chair |
YVES GENISSON
(UNIVERSITE PAUL SABATIER - LSPCMIB, Toulouse, France) |
| 15:30 | PL12 - Partnering Early to Better Serve Patients Suffering from Rare and Devastating Diseases |
Jean-Philippe ANNEREAU
(ALEXION, Paris, France) |
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| Session Chair |
Patrick JIMONET
(SANOFI, Vitry sur Seine, France) |
| 15:30 | PL13 - Allosteric Inhibitors of Dengue and Zika Virus NS3/NS2B Proteases |
Tanja SCHIRMEISTER
(UNIVERSITY OF MAINZ, Mainz, Germany) |
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|
| 16:15 | Coffee break & Exhibition |
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| Session 12: Synthetic Biology | Session 13: Tackling PPIs |
| Session Chair |
Sebastien PAPOT
(UNIVERSITY OF POITIERS, Poitiers, France) |
| 16:45 | PL14 - Xeno Nucleic Acids (XNA) in vivo : A New Medicinal Chemistry Approach? |
Piet HERDEWIJN
(KU LEUVEN, Leuven, Belgium) |
| 17:30 | PL16 - Bioactive Ribosomal and Non-Ribosomal Peptides from Nature - Structures, Biosynthesis and Engineering Options |
Roderich D. SÜSSMUTH
(TECHNICAL UNIVERSITY BERLIN, Berlin, Germany) |
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| Session Chair |
Andras KOTSCHY
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary) |
| 16:45 | PL15 - Monitoring the Antagonist-Protein and Protein-Protein Interactions with NMR and X-ray: Inhibitors of the p53-Mdm2 and Immune Checkpoint PD-1/PD-L1 Interactions |
Tad HOLAK
(MAX PLANCK INSTITUTE OF BIOCHEMISTRY, Krakow, Poland) |
| 17:30 | PL17 - Engineering Alphabodies to Generate Potent Druggable Inhibitors of Intracellular Protein-Protein Interactions |
Ignace LASTERS
(COMPLIX, Zwijnaarde, Belgium) |
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| 18:15 | End of Day 2 |
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| 19:00 | Cocktail at the City Hall |
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| 20:30 | Gala Dinner |
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| Friday July 7, 2017 |
| Session 14: Advances in Kinase Inhibitors Discovery & Development
Sponsored by Galapagos |
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| Session Chair |
Romain GOSMINI
(NOVALIX, llkirch-Graffenstaden, France) |
| 08:30 | PL18 - Development of Dual IGF1R/INSR Inhibitors - A Case Study |
Heather TYE
(EVOTEC LTD, Abingdon, United Kingdom) |
| 09:15 | PL19 - Identifying High Quality, Potent and Selective Inhibitors of ATM Kinase for Oncology Therapies: Discovery of AZD0156 |
Bernard BARLAAM
(ASTRAZENECA, Cambridge, United Kingdom) |
| 10:00 | Coffee break & Exhibition |
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| 10:30 | PL20 - Raising the Gold Standard: Design & Development of Highly Selective JAK3 Probes
(Janus Kinase 3)
|
Stefan LAUFER
(UNIVERSITY OF TÜBINGEN, Tübingen, Germany) |
| 11:15 | PL21 - Leniolisib (CDZ173) - Discovery of a New Generation of Potent and Selective PI3Kδ Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases |
Nicolas SOLDERMANN
(NOVARTIS, Basel, Switzerland) |
| Session 15: Pierre Fabre Award Lecture
Sponsored by Institut de Recherche Pierre Fabre |
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| Session Chair |
Michel PEREZ
(PIERRE FABRE, Toulouse, France) |
| 12:00 | PL22 - Creating, Varying and Selecting : The Driving Forces in Drug Discovery and Chemical Biology
Pierre Fabre Award lecture |
Benoit DEPREZ
(INSTITUT PASTEUR OF LILLE, Lille, France) |
| 13:00 | RICT 2017 Closing remarks & Prizes (Reaxys Award, Poster Prizes) |
Sebastien PAPOT
(UNIVERSITY OF POITIERS, Poitiers, France) |
| 13:15 | Introduction to RICT 2018 |
Dominique BONNET
(CNRS-UNIVERSITY OF STRASBOURG, Illkirch, France) |
| 13:30 | End of symposium |
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| 14:45 | Optional visit of the Airbus Facilities |
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