6th NovAliX Conference

Scientific Programme

Wednesday March 20, 2019
12:00Registration
13:15Welcome Address
Dr Jean-Paul RENAUD
(NOVALIX & RIBOSTRUCT, Illkirch, France)
Session 1: Hot Topics
Session Chair
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
13:30The Way Home: Molecular Recognition Path of L-TRP to IDO1 (OC01)
Prof. Antonio MACCHIARULO
(UNIVERSITY OF PERUGIA, Perugia, Italy)
13:45Fragment Based Screening: Critical Aspects of its Performance and Evaluation Screening a Diverse Set of Cancer Target Classes (OC02)
Dr Andrea GOHLKE
(BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom)
14:00High-Throughput, Automated Crystallography Pipelines for Drug Discovery (OC03)
Dr Irina CORNACIU
(EMBL GRENOBLE, Grenoble, France)
14:15Exhibitor Short Presentation: ForteBio
Integrated Solutions for Early Stage Biologics Discovery
14:25Structure of an Essential Inner Membrane Protein-LPS Complex (OC04)
Dr Thomas CLAIRFEUILLE
(GENENTECH, INC., South San Francisco, United States)
14:40Fragment Based Target Sreening to Prioritise Novel Antimicrobial Targets (OC05)
Dr Peter CANNING
(LIFEARC, Stevenage, United Kingdom)
14:55Biophysics as a Key Element in the Early Phase of Drug Discovery (IL01)
Dr Matthias FRECH
(MERCK, Darmstadt, Germany)
15:25Coffee Break & Exhibition
Session 2: X-ray Crystallography − Cryo-EM Complementarity
Session Chair
Dr Michael HENNIG
(LEADXPRO, Villigen, Switzerland)
15:55High-Resolution Structure Determination of Dynamic Macromolecular Complexes by Cryo-EM (IL02)
Prof. Holger STARK
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)
16:25Using X-ray and Cryo-EM Approaches to Study Allosteric Regulation of GTP Cyclohydrolase I (OC06)
Ms Rebecca EBENHOCH
(BOEHRINGER INGELHEIM, Biberach, Germany)
16:40Structural Studies of Chromatin Remodellers by Cryo-EM: Challenges and Opportunities for Drug Development (IL03)
Prof. Karl-Peter HOPFNER
(LUDWIG-MAXIMILIANS UNIVERSITY, München, Germany)
17:10Exhibitor Short Presentation: ThermoFisher Scientific
New Optical Modes to Improve Cryo-EM Throughput
17:20Cryo-EM, a New Tool for Drug Discovery at Novartis (IL04)
Dr Christian WIESMANN
(NOVARTIS, Basel, Switzerland)
Keynote Lecture
Chair
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
17:50Integrative Structural Biology of GPCRs (KL01)
Prof. Kurt WÜTHRICH
(THE SCRIPPS RESEARCH INSTITUTE, USA & ETH ZURICH, Zurich, Switzerland)
18:50Welcome Reception
20:00End of the Day
Thursday March 21, 2019
08:30Registration
Session 3: Chemical Biology Meets Biophysics for Drug Discovery
Session Chair
Dr Sandra JACOB
(NOVARTIS, Basel, Switzerland)
09:00Illuminating the Path to New E3-Ligases for Targeted Protein Degradation (IL05)
Ms Hannah LITHGOW (UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom)
 (BIOIB‚RICA)
09:30The Development and Biophysical Characterisation of Click-Tagged, Reversible Probes to Measure Target Occupancy of ERK1/2 Kinase Inhibitors (OC07)
Dr Chiara Rosa VALENZANO
(ASTEX PHARMACEUTICALS, Cambridge, United Kingdom)
09:45Biophysical and Structural Principles of PROTAC Mechanism of Action (IL06)
Prof. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
10:15Coffee Break & Exhibition
10:45The PROTAC Design Toolbox: Biophysically Enabling the Optimisation of a Potent SMARCA Degrader (OC08)
Dr David ZOLLMAN
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
11:00Exhibitor Short Presentation: Creoptix
Pushing Boundaries in Kinetics Analysis
11:10Rational Design of Kinase Inhibitors Using Structure and Biophysical Data (IL07)
Prof. Stefan KNAPP
(GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany)
11:40Poster Session
12:40Lunch, Exhibition & Networking
Session 4: MS-Based Methods
Session Chair
Dr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden)
14:00Advances in Structural Mass Spectrometry for Drug Discovery and Therapeutic Protein Characterization (IL08)
Dr Sarah CIANFERANI
(UNIVERSITY OF STRASBOURG, Strasbourg, France)
14:30Identifying an Escape Route from Adverse Effects of the Liver X Receptor Ligands Using HDX-MS (OC09)
Dr Anna BELORUSOVA
(ASTRAZENECA, Molndal, Sweden)
14:45Sugars in the Gas Phase? Novel Techniques to Unravel the Glycocode (IL09)
Prof. Kevin PAGEL
(FREIE UNIVERSITÄT BERLIN, Berlin, Germany)
15:15Exhibitor Short Presentation: Bruker Daltonics
High-Throughput SPR Screening in Drug Discovery
15:25Use of Mass Spectrometry in Small Molecule Lead Discovery (IL10)
Dr Jörg HOERNSCHEMEYER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)
15:55Coffee Break & Exhibition
Session 5: Characterisation of Small Molecules Binding to RNA
Session Chair
Dr Ursula EGNER
(BAYER, Berlin, Germany)
16:25Hit Discovery for Riboswitch Ligands (IL11)
Prof. Ruth BRENK
(UNIVERSITY OF BERGEN, Bergen, Norway)
16:55Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation (OC10)
Dr Margaret BUTKO
(BIODESY, South San Francisco, United States)
17:10Structural Basis for Gene-Specific RNA Splicing Correction Induced by a Small Molecule (IL12)
Prof. Frédéric ALLAIN
(ETH ZURICH, Zurich, Switzerland)
17:40Exhibitor Short Presentation: 2bind
Work with the Experts in Biophysics – A Quick Dive into 2bind’s Tailor-made Services for Drug Discovery
17:50Ribosomal Translation and Human Diseases (IL13)
Prof. Eric WESTHOF
(INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, Strasbourg, France)
18:20Poster Session & Drinks
19:20End of the Day
20:00Conference Dinner
Friday March 22, 2019
Session 6: Enabling Tools for Biophysical and Structural Studies
Session Chair
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
09:00Innovating Drug Discovery by Locking GPCRs in Functional Conformations (IL14)
Dr Christel MENET
(CONFO THERAPEUTICS, Brussels, Belgium)
09:30New Biophysical Approaches to Study IRES RNA/Ribosomes Interactions (OC11)
Dr Eric ENNIFAR
(CNRS, Strasbourg, France)
09:45Exhibitor Short Presentation: Synthelis
From Gene to Structure (FGTS)
09:55Strategies to Enable Challenging Biophysical and Structural Studies (IL15)
Dr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden)
10:25Coffee Break & Exhibition
10:55SPR-Based Approaches to Enable Direct Binding Assays for Membrane Proteins (IL16)
Dr Sylwia HUBER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)
11:25Impact of Mechanistic Enzymology and Bio-Structural Mass Spectrometry on the Progression of a Serine Hydrolase Inhibitor Discovery Project (OC12)
Dr Mathias ANTOINE
(INSTITUT DE RECHERCHES SERVIER, Croissy-Sur-Seine, France)
11:40An Integrated Molecular-Scale Biophysics Approach to Drug Discovery: the Contribution of the ARBRE-MOBIEU European Network (IL17)
Dr Patrick ENGLAND
(INSTITUT PASTEUR, Paris, France)
12:10Exhibitor Short Presentation: Crelux
Crelux – A Fully Integrated Offering, from Protein to Screen, Through Crystallography Confirmation and Beyond
12:20Wave-Guided Interferometry and Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (IL18)
Dr Nicolas BOCQUET
(LEADXPRO AG, Villigen, Switzerland)
12:50Poster Prizes and Closing Remarks
13:00Departure

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