Wednesday November 13, 2019 |
13:00 | Registration |
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13:45 | Welcome Address |
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| Session 1: Recent Advances in FBDD |
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| Session Chair |
Dr Mike HANN (GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom) |
14:00 | PhABits – Shining New Light on Fragments Approaches for Assessing Targets Tractability (IL01) |
Dr Mike HANN (GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom) |
14:30 | Fast Molecular Interaction Screening and Affinity Determination in Biophysical Drug Discovery Projects with Dianthus NT.23 and Tycho NT.6 (OC01) |
Mr Andreas LANGER (NANOTEMPER TECHNOLOGIES GMBH, Munich, Germany) |
14:45 | Targeting TIR Domain Assemblies in TLR Signaling Pathways to Design Anti-Inflammatory Compounds (OC02) |
Mr Md Habibur RAHAMAN (UNIVERSITY OF QUEENSLAND, Brisbane, Australia) |
15:00 | Ligand-Based Fluorine NMR Screening in Drug Discovery (IL02) |
Dr Anna VULPETTI (NOVARTIS, Basel, Switzerland) |
15:30 | Coffee Break & Exhibition |
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16:05 | Exhibitor Short Presentation: Crelux – A WuXi AppTec company
A Fragment-Based Approach to Leverage Challenging Targets: Human STING |
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16:15 | 19F NMR Screening Applied to Multiple Cancer Target (OC03) |
Dr Kenneth CAMERON (CRUK BEATSON INSTITUTE, Glasgow, United Kingdom) |
16:30 | Enabling Drug Discovery with Crude Reaction Mixture Screening (IL03) |
Dr Ben DAVIS (VERNALIS RESEARCH, Cambridge, United Kingdom) |
| Academia Keynote Lecture |
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| Session Chair |
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17:00 | Structure-biophysics Driven PROTAC Design for Degrading Undruggable Cancer Targets (KL01) |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
18:00 | Welcome Reception |
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19:30 | End of the Day |
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Thursday November 14, 2019 |
09:00 | Registration |
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| Session 2: Challenging Targets (GPCRs, Ion Channels...) |
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| Session Chair |
Dr Junichi SAITO (KYOWA KIRIN CO., LTD., Shizuoka, Japan) |
09:30 | Structural Biology of Seven-Transmembrane Receptors Toward Drug Discovery (IL04)
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Prof. Shigeyuki YOKOYAMA (RIKEN, Yokohama City, Japan) |
10:00 | Venturing into the Untapped: Discovery of Small-Molecule Drugs Targeting Messenger RNAs Using Biophysical and Computational Methods (OC04) |
Dr Ella MORISHITA (VERITAS IN SILICO, Tokyo, Japan) |
10:15 | Coffee Break & Exhibition |
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10:45 | Cryo-EM Structures Capturing the Transport Cycle of the P4-ATPase Flippase (OC05) |
Mr Masahiro HIRAIZUMI (MITSUBISHI TANABE PHARMA CORPORATION, Yokohama, Japan) |
11:00 | Advancing Cryo-EM for Determination of G Protein-Coupled Receptor Structure (IL05) |
Prof. Patrick M. SEXTON (MONASH UNIVERSITY, Parkville, Australia) |
11:30 | Poster Session |
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12:30 | Lunch Break, Exhibition & Networking |
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| Session 3: Cryo-EM in Drug Discovery |
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| Session Chair |
Dr Midori KAMIMURA (TEIJIN PHARMA LIMITED, Tokyo, Japan) |
14:00 | Cryo-EM Structural Studies of The Human TRPV4 Ion-Channel: Insights and Characterization of a Novel Open-Conformation (OC06) |
Dr Simon HOLTON (BAYER, Berlin, Germany) |
14:15 | Cryo-EM Application for Drug Discovery (OC07) |
Dr Wen-ti LIU (NOVALIX, Illkirch, France) |
14:30 | Advancing Drug Discovery in Pharma Using Cryo-EM (IL06) |
Dr Claudio CIFERRI (GENENTECH, South San Francisco, United States) |
15:00 | Exhibitor Short Presentation: Thermo Fisher Scientific
Cryo-EM Single Particle Analysis Productivity: the State of the Art |
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15:10 | Coffee Break & Exhibition |
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| Session 4: X-ray Crystallography / Cryo-EM Complementarity |
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| Session Chair |
Dr Denis ZEYER (NOVALIX, Illkirch, France) |
15:45 | Increased Performance in High-Throughput Compound and Fragment Screening Campaigns by the Use of "Club Class" Data Collection (IL07) |
Dr Gerard BRICOGNE (GLOBAL PHASING LTD., Cambridge, United Kingdom) |
16:15 | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase (IL08) |
Prof. Holger STARK (MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany) |
16:45 | Applying Hybrid Biophysical and Structural Methods to Study Allosteric Regulation of GTP Cyclohydrolase I - A Target for Treating Inflammatory and Neuropathic Pain (IL09) |
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
17:15 | Posters & Drinks |
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18:30 | End of the Day |
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20:00 | Conference Dinner |
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Friday November 15, 2019 |
08:30 | Registration |
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| Session 5: Hot Topics |
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| Session Chair |
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
09:00 | Re-energizing Small Molecule Drug Discovery by Centaur Chemist™ (IL10) |
Dr Daisuke TANAKA (EXSCIENTIA, Osaka, Japan) |
| Industry Keynote Lecture |
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| Session Chair |
Dr Mike HANN (GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom) |
09:30 | From Fragments to Pharmaceuticals (KL02) |
Dr Harren JHOTI (ASTEX PHARMACEUTICALS, Cambridge, United Kingdom) |
| Session 5: Hot Topics (continued) |
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| Session Chair |
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10:30 | Coffee Break & Exhibition |
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11:00 | Exhibitor Short Presentation: NanoTemper Technologies
Biophysical Tools for Measuring Binding Affinity, Protein Stability or Protein Quality with just a Tiny Amount of Sample |
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11:10 | Exhibitor Short Presentation: NovAliX
Single Particle Cryo-EM a Cutting Edge Service for Drug Discovery |
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11:20 | Uncovering a Ligand-Induced Twisted State of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance (OC08) |
Dr Dzung NGUYEN (PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany) |
11:35 | Structural Mechanisms of and Drug Discovery Targeting Substrate of Gamma-Secretase in Alzheimer's Disease (OC09) |
Prof. Chunyu WANG (RENSSELAER POLYTECHNIC INSTITUTE, Latham, United States) |
11:50 | Poster Prize and Closing Remarks |
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12:05 | End of the Conference |
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