15th EFMC Short Course on Medicinal Chemistry

Small Becomes Big in Medicinal Chemistry: Fragment-based Drug Discovery

 Oegstgeest (near Leiden), The Netherlands    April 28-May 1, 2019

Programme


17:00

Registration

19:00

Dinner

07:30

Breakfast

08:00

Opening

08:30

Introduction to Fragment Based Discovery – Overview of the Process and a Historical Perspective

Prof. Rod HUBBARD
UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom

10:30

Coffee Break

11:00

Design Principles for Fragment Libraries

Prof. Gyorgy KESERU
RESEARCH CENTRE FOR NATURAL SCIENCES, HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary

12:30

Lunch

13:30

Experiences and Issues with Biochemical Assays in Fragment-Based Drug Discovery

Dr Paul ENGLAND
IOTA PHARMACEUTICALS LTD., Cambridge, United Kingdom

15:00

Coffee Break

15:30

Biophysical Fragment Based Screening

Dr Ben DAVIS
VERNALIS PLC, Cambridge, United Kingdom

17:30

Day End

18:00

Walking tour through Leiden

19:00

Dinner in Leiden

07:30

Breakfast

08:30

Why Fragments Make Sense and Actually Work

Dr Mike HANN
GLAXOSMITHKLINE, Stevenage, United Kingdom

10:30

Coffee Break

11:00

Computational Approaches for Fragment Screening and Fragment Evolution

Dr Xavier BARRIL
UNIVERSITY OF BARCELONA & GAIN THERAPEUTICS, Barcelona, Spain

12:30

Lunch

13:30

Applications of FBDD

Dr Greg SIEGAL
ZOBIO BV, Leiden, The Netherlands

15:00

Coffee Break

15:30

Application-Project in group (Part 1)

17:30

Day End

19:00

Dinner

07:30

Breakfast

08:30

Application-Project in group (Part 2)

10:30

Coffee Break

11:00

Presentations of the results

12:00

Wrap-up and Lunch