6th NovAliX Conference

Confirmed Speakers


Keynote Lecture

Integrative Structural Biology of GPCRs (KL01)
Prof. Kurt WÜTHRICHProf. Kurt WÜTHRICH
(THE SCRIPPS RESEARCH INSTITUTE, USA & ETH ZURICH, Zurich, Switzerland)

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Session 1: Hot Topics

Fragment Based Target Sreening to Prioritise Novel Antimicrobial Targets (OC05)
Dr Peter CANNINGDr Peter CANNING
(LIFEARC, Stevenage, United Kingdom)

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Structure of an Essential Inner Membrane Protein-LPS Complex (OC04)
Dr Thomas CLAIRFEUILLEDr Thomas CLAIRFEUILLE
(GENENTECH, INC., South San Francisco, United States)

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High-Throughput, Automated Crystallography Pipelines for Drug Discovery (OC03)
Dr Irina CORNACIUDr Irina CORNACIU
(EMBL GRENOBLE, Grenoble, France)

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Biophysics as a Key Element in the Early Phase of Drug Discovery (IL01)
Dr Matthias FRECHDr Matthias FRECH
(MERCK, Darmstadt, Germany)

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Fragment Based Screening: Critical Aspects of its Performance and Evaluation Screening a Diverse Set of Cancer Target Classes (OC02)
Dr Andrea GOHLKEDr Andrea GOHLKE
(BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom)

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The Way Home: Molecular Recognition Path of L-TRP to IDO1 (OC01)
Prof. Antonio MACCHIARULOProf. Antonio MACCHIARULO
(UNIVERSITY OF PERUGIA, Perugia, Italy)

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Session 2: X-ray Crystallography − Cryo-EM Complementarity

Using X-ray and Cryo-EM Approaches to Study Allosteric Regulation of GTP Cyclohydrolase I (OC06)
Ms Rebecca EBENHOCHMs Rebecca EBENHOCH
(BOEHRINGER INGELHEIM, Biberach, Germany)

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Structural Studies of Chromatin Remodellers by Cryo-EM: Challenges and Opportunities for Drug Development (IL03)
Prof. Karl-Peter HOPFNERProf. Karl-Peter HOPFNER
(LUDWIG-MAXIMILIANS UNIVERSITY, München, Germany)

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High-Resolution Structure Determination of Dynamic Macromolecular Complexes by Cryo-EM (IL02)
Prof. Holger STARKProf. Holger STARK
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)

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Cryo-EM, a New Tool for Drug Discovery at Novartis (IL04)
Dr Christian WIESMANNDr Christian WIESMANN
(NOVARTIS, Basel, Switzerland)

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Session 3: Chemical Biology Meets Biophysics for Drug Discovery

Biophysical and Structural Principles of PROTAC Mechanism of Action (IL06)
Prof. Alessio CIULLIProf. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)

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Rational Design of Kinase Inhibitors Using Structure and Biophysical Data (IL07)
Prof. Stefan KNAPPProf. Stefan KNAPP
(GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany)

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Illuminating the Path to New E3-Ligases for Targeted Protein Degradation (IL05)
Ms Hannah LITHGOWMs Hannah LITHGOW
(UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom)

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The Development and Biophysical Characterisation of Click-Tagged, Reversible Probes to Measure Target Occupancy of ERK1/2 Kinase Inhibitors (OC07)
Dr Chiara Rosa VALENZANODr Chiara Rosa VALENZANO
(ASTEX PHARMACEUTICALS, Cambridge, United Kingdom)

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The PROTAC Design Toolbox: Biophysically Enabling the Optimisation of a Potent SMARCA Degrader (OC08)
Dr David ZOLLMANDr David ZOLLMAN
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)

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Session 4: MS-Based Methods

Identifying an Escape Route from Adverse Effects of the Liver X Receptor Ligands Using HDX-MS (OC09)
Dr Anna BELORUSOVADr Anna BELORUSOVA
(ASTRAZENECA, Molndal, Sweden)

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Advances in Structural Mass Spectrometry for Drug Discovery and Therapeutic Protein Characterization (IL08)
Dr Sarah CIANFERANIDr Sarah CIANFERANI
(UNIVERSITY OF STRASBOURG, Strasbourg, France)

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Use of Mass Spectrometry in Small Molecule Lead Discovery (IL10)
Dr Jörg HOERNSCHEMEYERDr Jörg HOERNSCHEMEYER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)

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Sugars in the Gas Phase? Novel Techniques to Unravel the Glycocode (IL09)
Prof. Kevin PAGELProf. Kevin PAGEL
(FREIE UNIVERSITÄT BERLIN, Berlin, Germany)

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Session 5: Characterisation of Small Molecules Binding to RNA

Structural Basis for Gene-Specific RNA Splicing Correction Induced by a Small Molecule (IL12)
Prof. Frédéric ALLAINProf. Frédéric ALLAIN
(ETH ZURICH, Zurich, Switzerland)

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Hit Discovery for Riboswitch Ligands (IL11)
Prof. Ruth BRENKProf. Ruth BRENK
(UNIVERSITY OF BERGEN, Bergen, Norway)

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Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation (OC10)
Dr Margaret BUTKODr Margaret BUTKO
(BIODESY, South San Francisco, United States)

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Ribosomal Translation and Human Diseases (IL13)
Prof. Eric WESTHOFProf. Eric WESTHOF
(INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, Strasbourg, France)

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Session 6: Enabling Tools for Biophysical and Structural Studies

Impact of Mechanistic Enzymology and Bio-Structural Mass Spectrometry on the Progression of a Serine Hydrolase Inhibitor Discovery Project (OC12)
Dr Mathias ANTOINEDr Mathias ANTOINE
(INSTITUT DE RECHERCHES SERVIER, Croissy-Sur-Seine, France)

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Wave-Guided Interferometry and Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (IL18)
Dr Nicolas BOCQUETDr Nicolas BOCQUET
(LEADXPRO AG, Villigen, Switzerland)

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An Integrated Molecular-Scale Biophysics Approach to Drug Discovery: the Contribution of the ARBRE-MOBIEU European Network (IL17)
Dr Patrick ENGLANDDr Patrick ENGLAND
(INSTITUT PASTEUR, Paris, France)

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New Biophysical Approaches to Study IRES RNA/Ribosomes Interactions (OC11)
Dr Eric ENNIFARDr Eric ENNIFAR
(CNRS, Strasbourg, France)

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Strategies to Enable Challenging Biophysical and Structural Studies (IL15)
Dr Stefan GESCHWINDNERDr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden)

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SPR-Based Approaches to Enable Direct Binding Assays for Membrane Proteins (IL16)
Dr Sylwia HUBERDr Sylwia HUBER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)

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Innovating Drug Discovery by Locking GPCRs in Functional Conformations (IL14)
Dr Christel MENETDr Christel MENET
(CONFO THERAPEUTICS, Brussels, Belgium)

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